DVS Endeavour

DVS Endeavour

5X Parallel Gravimetric Sorption Analyzer

A key feature of DVS Endeavour is the ability to precisely control and measure temperature and relative humidity while simultaneously recording the highest resolution changes in mass on up to 5 samples. Additionally Organic vapor partial pressures can now be directly measured using Surface Measurement Systems’ Speed of Sound sensor (patented). In a typical experiment a known concentration of water vapor or organic vapor is delivered over a sample placed inside the sample pan. The sample pan is connected to the Surface Measurement Systems Ultrabalance measuring real-time mass changes caused by sorption or desorption of water and/or organic molecules.

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Outstanding capabilities

5x sample

Organic and
Water vapor
sorption kinetics

Organic vapor sorption in a fixed RH background

Real time partial pressure control & measurement

Water & organic vapor sorption isotherms from 10-70 °C

In-situ drying
of samples
to 200 °C

Color Video

drying at
0.0% RH

  • Real-time simultaneous parallel mass measurements and sorption kinetics for up to 5 samples
  • Individual sample chamber isolation preventing crossover contamination
  • Sample masses from 1 mg to 5000 mg
  • Water and organic vapor sorption kinetics and control using patented Speed of Sound vapor sensor measurementtechnology
  • Multiple sorption/desorption, temperature and sample drying or activation cycles

Lot-to-Lot Moisture Sorption/Desorption Variation of Microcrystalline Cellulose

  • Investigation of batch-to-batch variation in raw materials and production technicalsupport
  • Ingredient compatibility
  • Quality control for excipients, actives and formulations
  • Stability studies in the selection of new compounds/candidates
  • Large scale formulation studies

Moisture Sorption/Desorption variation within the same lot of Crystalline material

  • Isotherms and ramped humidity/organic vapor and experiments
  • Vapor sorption, vapor exchange and dual vapor co-adsorption

Processing Variations Affect Amorphous Content and Humidity Sorption/Desorption of Milk Powder

  • Amorphous content
  • Hydrate/solvate formation
  • Polymorph identification
  • Moisture/solvent induced Tg

Humidity Sorption/Desorption Kinetics and Isotherms

Sorption Isotherms for Moisture and a Series of Organic Vapors

Film Diffusion Coefficient for Moisture Barrier Coatings


Temperature controlled enclosure

  • Control range: 10 °C to 70 °C
  • Regulation precision: ± 0.1 oC
  • Enclosure also provides anti-condensation protection

High temperature pre-heater for drying samples up to 200 °C

  • 200 °C (maximum local temperature)
  • Heating ramp rates: up to 10 °C/min
  • Temperature Sensor: Pt-100

Endeavour Stand

  • Manifold: 316 stainless steel
  • Seals: Viton
  • Tubing: 1/4 inch stainless steel

Solvent Reservoirs

  • Material: Pyrex glass
  • 0.25 and 0.5L as standard
  • 2 Reservoirs included

Relative Humidity Generation and Measurement

Flow control

  • High accurate digital mass flow controllers

Relative Humidity Sensor

  • Capacitance probe
  • Carrier Gas – Dry air or Nitrogen
  • Relative humidity range from 0 to 98%
  • RH range accuracy from 10 – 60 oC ±0.5%
  • RH range accuracy from 60 – 70 oC ±1%

Organic Vapor Generation and Measurement Speed of Sound Sensor

  • Partial pressure range from 0 to 90%
  • P/P0 range accuracy from 10 – 50 oC ±1%
  • Speed of Sound Sensor for organic vapors
  • Real time partial pressure measurement and control

Solvents Available include:

  • Water
  • Pentane
  • Heptane
  • Hexane
  • Octane
  • Nonane
  • Decane
  • Cyclohexane
  • Methanol
  • Ethanol
  • Phenol
  • Toluene
  • Acetone
  • Chloroform
  • o-Xylene
  • m-Xylene
  • p-Xylene
  • Benzyl Acetate
  • Ethyl Acetate
  • d-Limonene
  • Tetrahydrofuran
  • Dioxane
  • Dichloromethane
  • Isopropanol

Instrument Platform

System Software
Next generation purpose built analysis and evaluation software for
the most advanced experimental design and data control.

DVS Control Software
Multiple-method protocols

  • Sample pre-heating
  • Vapor sorption
  • Vapor exchange
  • Dual vapor co-adsorption
  • Temperature changes in a single experiment
  • Ramp or step changes in relativehumidity
  • Automated video image acquisition
  • Organic vapor sorption partialpressure
  • Temperature stages may be based on fixed-time or user-defined dm/dt criteria
  • Complex isotherm experiments
  • Experiments may include half, full or multiple partial pressure or temperature cycles

Software Options

  • DVS Control Software
  • DVS Standard Analysis


  • DVS Advanced Analysis Suite
  • DVS Isotherm Analysis Suite

21CFR Part 11 software solution is available for all DVS software upon request

Mass Measurement

Ultrabalance Low Mass

  • Low Mass SMS microbalance
  • Sample mass: between 1 and
  • 1000 mg
  • Mass change: ±150 mg
  • Resolution (precision): 0.01 μg
  • Root mean square balance noise:  0.3 μg

Ultrabalance High Mass

  • High Mass SMS microbalance
  • Sample mass: between 10 and 5000 mg
  • Mass change: ±1000 mg
  • Resolution (precision): 1 μg
  • Root mean square balance noise:  3 μg

For more information, email [email protected].