Online Workshop:
Advanced sorption methods for particle characterization in pharma research

Weds 11 May 2022
2:00 pm BST | 3:00 pm CEST | 9:00 am EDT
2 hours incl. Q&A

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Dr. Christian Lübbert

Dr. Susannah Molisso
Surface Measurement Systems

Connor Hewson
Surface Measurement Systems

Workshop partners:

We are excited to invite you to our next online workshop, organized in collaboration with Amofor and the University of Dortmund. Advanced sorption techniques can be essential characterization tools in the research and development of new pharmaceutical compounds and materials. In this session, we will give you a deep understanding of advanced gravimetric sorption techniques, such as Dynamic Vapor Sorption (DVS) and Inverse Gas Chromatography (iGC), and how they can be employed to gain unparalleled detail and accuracy in materials research.

Along with special guest speaker Dr. Christian Lübbert (Amofor) exploring some of his recent research, the workshop will feature two leading Application Science experts from Surface Measurement Systems, Dr. Sussanah Molisso and Connor Hewson.

Read the full agenda and abstracts below, and sign up free here.


Dr. Christian Lübbert, amofor GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany

An amorphous solid dispersion (ASD) is a state-of-the art formulation technique to enable sufficient bioavailability of poorly-water-soluble active pharmaceutical ingredients (APIs). In an ASD, the API is dissolved in a polymer to prevent recrystallization during shelf life.

Intermolecular interactions between API and polymer must be understood to predict the optimal API load in an ASD, the ASD shelf life or ASD processing parameters for manufacturing processes (e.g. spray drying). This webinar will elucidate the strong potential of combining dynamic vapor sorption (DVS) measurements with thermodynamic modeling as universal tool for formulation development far beyond regular water sorption determinations.

Based on sorption measurements in an ASD and thermodynamic modeling, the crystalline solubility of an API in a polymer is predictable quickly requiring minimal sample amount (<2mg API per API/polymer combination). This method is beneficial compared to techniques like the melting point depression method via differential scanning calorimetry, as the sorption data is acquired at storage test relevant temperatures and not diffusion velocity limited. Additionally, a method to predict the ASD shelf life only based on DVS and modeling is presented. One DVS measurement characterizing the crystallization velocity of the API at harsh conditions (to obtain the glass stability of the pure API) and one ASD diffusion measurement (to obtain the viscosity of the ASD as function of relative humidity). With this minimal data set, the shelf life of an ASD at different storage and humidity conditions (months to years) can be predicted in advance by the measurements (few days) and the modeling only.

During spray drying process development, the optimal solvent or solvent mixture must be identified dissolving polymer and API sufficiently. This is again possible with DVS only, as sorption measurements combined with thermodynamic modeling allow via extrapolations even reliable miscibility and solubility predictions.

The entire ASD formulation development is enhanced by DVS measurements combined with thermodynamic modeling. Scientists have a powerful combined tool at hand, as experiments require minimal sample amount and results from calculations are obtained within minimal time.

with Dr. Christian Lübbert, Amofor

Meishan Guo*1, Majid Naderi1, Connor Hewson1, Manaswini Acharya1 and Daniel Burnett2

1Surface Measurement Systems Ltd., Alperton, London, HA04PE

2Surface Measurement Systems Ltd., 2125 28th Street SW, Suite 1, Allentown, PA 18103, USA

The surface energy of the starting, intermediate or final products is an important factor in understanding the processing operation and/or the final product performance. This study will consider the surface energy and surface energy heterogeneity of crystalline solids, methods for the measurement of surface energy, effects of milling on powder surface energy, adhesion and cohesion on powder mixtures, crystal habits and surface energy as well as surface energy and powder granulation processes to predict agglomeration and powder flow behaviour, using surface energy heterogeneity and work of adhesion to cohesion ratio as the parameters.

with Dr. Susannah Molisso, Surface Measurement Systems

Meishan Guo*1, Majid Naderi1, Connor Hewson1, Manaswini Acharya1 and Daniel Burnett2

1Surface Measurement Systems Ltd., Alperton, London, HA04PE

2Surface Measurement Systems Ltd., 2125 28th Street SW, Suite 1, Allentown, PA 18103, USA

Drug substances intended for drug delivery to the lungs typically require particle size reduction. High energy processes are utilized to produce particles smaller than 10μm but these processes are also known to influence crystallinity, which can lead to a reduction in physical and sometimes even chemical stability. Therefore, these materials may be conditioned following micronization before further processing. Such a “deamorphization” step typically involves the treatment of the materials with an appropriate solvent that plasticizes the material and induces crystallization. While the selection of the solvent is critical, the degree of control over the deamorphization process is also very important. A treatment time that is too short may lead to incomplete crystallization of the material, while overtreatment may cause partial dissolution and agglomeration. In order to estimate the appropriate treatment time, knowledge of the crystallization kinetics may be predicted from Dynamic Vapour Sorption (DVS) studies over a wide range of temperature and humidity conditions. Water vapor has been shown to induce crystallization for milled salbutamol sulphate, with one-step mechanism.

with Connor Hewson, Surface Measurement Systems

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