Webinar: Study of particle cohesion/adhesion and wettability of powders
and formulations

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Date: Thursday, 4 June 2020

Time: 15:00 BST | 16:00 CEST | 10:00 EDT
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Duration: 25 mins plus Q&A

The effect of powder surface chemistry on high shear wet granulation performance for co-agglomerating untreated and silanized D-mannitol powder is discussed. The wetting performance of polyvinylpyrrolidone (PVP) binder solutions was quantified using experimentally determined thermodynamic spreading coefficients, using the surface energy heterogeneity distributions, obtained via inverse gas chromatography (iGC) measurements, for the mannitol powders. Increases in binder wettability of the formulations correlated with increases in both granule size and granule compressive elastic moduli, which are attributed to an increase in interparticle contacts. In conclusion, powder surface chemistry plays a crucial role in final granule properties, even in highly agitated processes such as high shear granulation. The comprehensive characterization of powder surface properties is necessary to facilitate the manufacture of granules with controllable critical attributes.

This webinar will present the study of the role of solid state surface chemistry on the high shear granulation performance of a model pharmaceutical solids.


Prof Daryl Williams

Prof. Daryl Williams Prof. Daryl R. Williams graduated with a B.Sc. (Hons) in Physical Chemistry from University of Melbourne, Australia and a M.Sc. in Polymer Science from Lehigh University, USA before coming to Imperial College London complete his PhD. He is founder and Managing Director of Surface Measurement Systems and the Professor of Particle Science in the Department of Chemical Engineering at Imperial College.

Prof. Williams has published over 100 papers in refereed journals and been granted international 5 patents. His research interests include the surface and bulk characterisation of complex organic solids, including especially biopharmaceutics, foods, pharmaceuticals and polymers as well as their manufacture using spray drying, crystallisation, freeze drying, milling and granulation. The Surface and Particle Engineering Laboratory at Imperial College he leads has 4 Postdoctoral research fellows and 11 PhD students.

He has invented one and has led the commercialisation of two standard techniques for materials characterisation, the Dynamics Vapour Sorption (DVS) and the Inverse Gas Chromatography (IGC) methods via Surface Measurement Systems. His work has been recognised by Imperial College with the President’s Medal in 2017, the EEF’s Future Manufacturing Award in Innovation for 2018 and the Institution of Chemical Engineers’ Geldart Medal in 2018/19 for his “major contribution to particle technology”.

For more information, email Zen Limuco [email protected]

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