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Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations

Date: Wednesday, 4 November 2015

Time: 10am (GMT) & 2pm (EST)

Location: Online

Event type: Webinar

Topic: Engineers and pharmacists need to understand and control a range of key unit manufacturing operations such as milling, granulation, crystallisation, powder mixing and dry powder inhaled drugs which can be very challenging. It has now become very clear that in many of these particle processing operations, the surface energy of the starting, intermediate or final products is a key factor in understanding the processing operation and or the final product performance. This webinar will review the surface energy and surface energy heterogeneity of crystalline solids, methods for the measurement of surface energy, effects of milling on powder surface energy, adhesion and cohesion on powder mixtures, crystal habits and surface energy, surface energy and powder granulation processes. The use and development of inverse gas chromatographic methods will be especially highlighted. And will conclude that the importance of surface energy as an important factor in understanding the performance of many particulate pharmaceutical products and processes has now been clearly established. It is still nevertheless, work in progress both in terms of development of methods and establishing the limits for when surface energy is the key variable of relevance.

Presenter: Dr. Daryl R. Williams

Dr Daryl Williams graduated with a B.Sc. (Hons) in Physical Chemistry from University of Melbourne, Australia and a M.Sc. in Polymer Science from Lehigh University, USA before coming to Imperial College London to start his Ph.D. Daryl has published over 80 papers in refereed journals, been granted international 5 patents and speaks regularly at international conferences and workshops. He has expertise in advanced materials characterisation and is a world leader in advanced instrumental characterisation of solids. He is also the founder of Surface Measurement Systems and inventor of the Dynamic Vapor Sorption method as well as the Surface Energy Analyser instrument, now used in over 1000 laboratories throughout the world. Surface Measurement Systems is the technological market leader in advanced vapour sorption instruments for materials characterisation.

He is also the Director of the Discovery Space and a Reader in Particle Science in the Department of Chemical Engineering at Imperial College. Imperial College is consistently rated in the top 5 universities in the world and the Chemical Engineering Department is one of the largest and top rated departments internationally.

Format: 45-minute presentation

Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations