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Application Note 501: Environmental Microscopy using the GenRH-A Humidity Generator and Mcell Accessory
Humidity can have a dramatic effect on the formulation, development, and performance of a wide range of materials. Therefore, it is important to study material physical properties over a range of real-world humidity and temperature conditions. This note utilizes the GenRH and Mcell accessory for light and FT-IR microscopy applications.

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Application Note 502: Raman Spectrum of Morphine Sulphate Using Confocal Raman
Use of confocal Raman microscopy with vapour generator & microscopy cell is investigated on Morphine Sulphate.

Application Note 503: Investigating Dried Milk Powders Using Optical Microscopy at Different Humidity Conditions
Humidity can have a profound effect on the formulation, processing behaviour, stability and shelf-life of a wide range of materials. In particular, food materials are especially sensitive to water vapour. This application note demonstrations how variations between three similar dried milk samples can be compared directly using optical microscopy as a function of relative humidity. Also, this note will address the advantages that direct comparison between different samples can bring.

Application Note 504: Water Vapor Induced Mesoporous Structure Collapse Observed by GenRH with Mcell
and FT-IR
Humidity can have a profound effect on the formulation, processing behaviour, stability and shelf-life of a wide range of materials. In particular, food materials are especially sensitive to water vapour. This application note demonstrations how variations between three similar dried milk samples can be compared directly using optical microscopy as a function of relative humidity. Also, this note will address the advantages that direct comparison between different samples can bring.

Application Note 505: Identifying Structural Changes in the Protein Collagen Using Humidity Generation and FT-IR
Progress in biotechnology in recent years has precipitated renewed interest in the interaction of proteins with each other and the environment. Collagen’s function as one of the fundamental structural features of biological systems makes it a protein of prime interest in areas as diverse as trans-dermal drug delivery, pre-cancerous cell diagnosis and bone regeneration. Described herein is an account of preliminary studies of the effect of RH and temperature on the protein and how humidity generation instrumentation combined with FT-IR can be used to quickly demonstrate structural change in proteins.

Application Note 506: Humidity control for MEMS
The advent of MEMS (Micro Electrical Mechanical Systems) promises new advances in almost all areas of technology, but also brings with it issues that challenge the successful commercialisation of this technology. Highlighted here is the role that humidity plays in hindering the progress of this technology.

Application Note 507: Raman Spectroscopy of Hydration State changes of active Pharmaceutical ingredients
The influence of hydration states of active pharmaceutical ingredients on their crystallinity is an important factor in drug development, as changes in crystallinity also affect solubility, dissolution rate, stability and bio-availability of the drug. Knowledge of the influence of humidity on the stability of different states therefore becomes essential from both a safety and regulatory point of view. Raman spectroscopy is an ideal tool for observing the molecular changes that occur through changes induced in the spectrum, and when used in conjunction with the vapour generator and microscopy cell, can provide considerable information relating to the effects of any humidity changes on crystallinity and the packing on different functional groups of the molecules. This study focuses on the humidity induced changes occurring in two anti-inflammatory drugs used in the treatment of asthma; disodium cromoglycate, and nedocromil sodium.

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To learn more about applications 502, 503, 504, 505, 506 and 507 please contact Jan Gorgol or call our UK office at +44 208 795 9400/ US office +1 610 798 8299.