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2015 AAPS Annual Meeting and Exposition

Surface Measurement Systems was again pleased to continue support of the AAPS society through participation in the exhibit and scientific program at the annual meeting in Orlando.

At the conference we presented the latest applications in gravimetric vapor sorption and surface energy heterogeneity for solid state and process characterization. If you were unable to join us at the show, but would still like a copy of our posters please download using the links below:

AAPS 2015 Posters

M1203 – Effects of Surface Energy Heterogeneity of API/Excipient Blends on Blend Uniformity

Blend uniformity is a function of both the formulation and processing conditions. Poor uniformity creates lots of waste, resulting in loss of revenue for manufacturers. Many chemical and physical properties like particle size, particle shape, and surface properties can affect mixing behavior. When these properties differ between active components and excipients, de-mixing effects can occur. In this study, the surface energy values of paracetamol, lactose, mixtures of the two, and final capsule blend have been measured to investigate their potential effects on blend uniformity.  <Download>

T3296 – Moisture Sorption Properties of Different Poloxamer Grades

Water sorption properties are crucial for physical characterization of excipients used in pharmaceutical formulation. An important group of excipients is Poloxamers, which are nonionic triblock copolymers composed of a central hydrophobic block of polypropylene glycol, covalently linked with two hydrophilic blocks of polyethylene glycol on each side. The water sorption isotherms of Poloxamers are important because of lack of such data in the literature. This is relevant for a robust formulation development. In this study, we investigated the moisture sorption for a range of Poloxamer grades. <Download>

M1221 – The Surface Energy of Mannitol Polymorphs

The surface energy of solids is important as it governs a range of solid-liquid and solid-solid interactions. Surface energy influences processing-ability of powders, performance of a formulation, and is hypothesized to differ for polymorphs. This study outlines the application of surface energy mapping by Finite Dilution Inverse Gas Chromatography (FD-IGC) to determine the surface energy distributions of mannitol polymorphs. <Download>

W4123 – Impact of Flow Rate and Exposure Time on Humidity-Induced Crystallization of Salbutamol Sulphate

The deposition of active ingredients, delivered via dry powder inhalers is known to be affected by the humidity in the lung. Humidity effects can cause a change in the aerodynamic particle size distribution due to hypertonic shrinkage or hypotonic growth

[1]. Other factors are agglomeration of particles facilitated by crystallization of amorphous sites on the particle surface. A similar mechanism is also dominant for the condensational growth of nanoaerosol particles in the upper airways [1]. While these factors are well known, it is poorly understood whether the equilibrium between lung humidity and particle surface is fully established. This depends on the inspiratory flow rate and exposure time of a particle in the airways [2]. Especially in the case of agglomeration due to crystallization of amorphous sites the above-mentioned factors strongly affect the crystallization kinetics and therefore the degree of agglomeration/ crystallization. This study investigates the flow rate and exposure time dependency of water-induced crystallization of salbutamol sulphate (SS) as a model compound at high humidity. <Download>

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